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PubMed COVID-19 Clinical Care

12271 - 12280 of 44979 results found

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

Date
Wednesday, November 22, 2023 - 4:00 AM
Description
The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19 vaccine compositions. However, immune imprinting induced by vaccination based on the ancestral (hereafter referred to as WT) strain would compromise the antibody

Immune imprinting as a barrier to effective COVID-19 vaccines

Date
Wednesday, November 22, 2023 - 4:00 AM
Description
Wang and colleagues show that immune imprinting impairs neutralizing antibody titers for bivalent mRNA vaccination against SARS-CoV-2 Omicron subvariants. Imprinting from three doses of monovalent vaccine can be alleviated by BA.5 or BQ-lineage