Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination
Description
The Spike glycoprotein of SARS-CoV-2 mediates viral entry into the host cell via the interaction between its receptor binding domain (RBD) and human angiotensin-converting enzyme 2 (ACE2). Spike RBD has been reported to adopt two primary
