A proofreading mutation with an allosteric effect allows a cluster SARS-CoV-2 viruses to rapidly evolve
Description
The RNA dependent RNA polymerase (RdRp) of the SARS-CoV-2 virus is error prone, with errors being corrected by the exonuclease (NSP14) proofreading mechanism. However, the mutagenesis and subsequent evolutionary trajectory of the virus is mediated by
